New insights. Translatomics.

Wir wollen dem Leben in den Rachen greifen. Translation ist die wirkungsvollste regulatorische Ebene des Lebens.
扼住生命的咽喉。翻译调控是生命中最重要的调控层次。

 

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大量“非编码基因”可以表达蛋白质

生物通 2018.11.7.

暨南大学张弓教授:刷新蛋白质组谱重现性记录

生物通 2019.6.12.

环状RNA翻译出抑癌蛋白质!

生物通 2018.11.7.

暨南大学张弓教授:制定蛋白质组“开放式搜索”质控标准

生物通 2018.10.22.

本实验室参与申报的科技部国家重点研发计划《医学生命组学数据质量控制关键技术研发与应用》项目立项。

基因谷 2018.9.19. 头条

FANSe3 算法创世界纪录,一小时全基因组、一分钟全外显子组分析

南方日报 2018.1.22.

张弓课题组联合承启生物在Nucleic Acids Research发表最强翻译组学数据库 TranslatomeDB

暨南大学生命科学技术学院 2017.11.24.

暨大研发另类质谱鉴定算法策略, 零成本大幅提高蛋白质组鉴定能力

生物通 2017.10.24.

TranslatomeDB
翻译组学数据库

TranslatomeDB provides collection and integrated analysis of published and user-generated translatome sequencing data (mRNA-seq, RNC-seq, Ribo-seq). All datasets are analyzed using a unified, robust, accurate and experimentally-verifiable FANSe3 algorithm for read mapping and edgeR for DGE analysis.

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FANSe3

Mapping algorithm for Next-generation sequencing
大规模测序高速序列比对算法

FANSe3 is the third generation of FANSe series mapping algorithm, which maps millions and billions of sequencing reads to reference sequences. Unlike the other NGS mapping algorithms, which prioritize the speed and then try to compensate the accuracy, the FANSe series algorithm is prioritized to guarantee the accuracy and robustness, and using computational optimization to speed up.

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FANSe2

Mapping algorithm for Next-generation sequencing
大规模测序高速序列比对算法

FANSe2 is a mapping algorithm which can map a billion reads in hours with ultimate and robust accuracy. Compared with FANSe, FANSe2 inherited the near-perfect and robust accuracy while making substantial strategic and technical improvements, increasing the running speed for more than 10x and thus is suitable for large reference genome sequences.

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FANSe2splice

Spliced mapping algorithm for RNA-seq
RNA测序剪切mapping算法

FANSe2splice is a mapping tool for spliced mapping for next-generation sequencing. It splits a read into two halves and map them to reference genome. This is particularly useful in case of RNA-seq, where RNA splicing may occur. FANSe2splice inherited accuracy and robustness from FANSe2. It detects junction from single-end reads. It detects junctions from a single read without the aid of any other reads, and thus ideal for low-throughput sequencing.

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RiboTempo

Predicting translation pausing sites based on tRNA abundance
基于tRNA丰度预测翻译暂停

RiboTempo predicts the translation rate profile in E. coli and B. subtilis. The algorithm incorporates calculation of the rate of translation of each codon based on the tRNA concentration and codon selectivity of the cognate tRNA. Please refer to the citations.

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